To some adults all liquid medicines produce such nausea that pills are the only form in which aperients can be exhibited; the following is a useful formula: i. Take of compound rhubarb pill a drachm and one scruple, of powdered ipecacuanha ten grains, and of extract of hyoscyamus one scruple; mix, and beat into a mass, and divide into twenty-four pills; take one or two, or if of a very costive habit, _three_ at bedtime. ii. For persons requiring a more powerful aperient, the same formula, with twenty grains of compound extract of colocynth, will form a good purgative pill. The mass receiving this addition must be divided into thirty, instead of twenty-four pills.